Examining the roles of DNA2 during mammalian end resection

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چکیده

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Examining the roles of DNA2 during mammalian end resection

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Molecular and Cellular Pathobiology Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection

In precancerous and cancerous lesions, excessive growth signals resulting from activation of oncogenes or loss of tumor suppressor genes lead to intensive replication stress, which is recognized by a high level of replicationassociated DNA double-strand breaks (DSB). However, the molecular mechanism by which cells alleviate excessive replication stress remains unclear. In this study, we report ...

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ژورنال

عنوان ژورنال: Cell Cycle

سال: 2012

ISSN: 1538-4101,1551-4005

DOI: 10.4161/cc.22605